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Stroke risk predicts verbal fluency decline in healthy older men
 — evidence from the Normative Aging Study
Author(s)Christopher B Brady, Avron Spiro III, Regina McGlinchey-Berroth
Journal titleJournals of Gerontology: Series B, Psychological Sciences and Social Sciences, vol 56B, no 6, November 2001
Pagespp P340-P346
KeywordsStroke ; At risk ; Cognitive processes ; Older men ; United States of America.
AnnotationRisk factors for stroke cause ischaemic changes on the cerebral white matter that may affect frontal lobe function more than other brain functions. Therefore stroke risk could specifically affect performance on behavioural indexes traditionally associated with frontal lobe function such as verbal fluency. The authors examined this hypothesis in 235 healthy older men (mean age 66.41) who received concurrent medical and neuropsychological examinations twice at a 3-year interval. Relationship between stroke risk and decline in verbal fluency, memory, and visuo-spatial performance were analysed through regression, controlling for age and education. Age was associated with decline in all cognitive functions; stroke risk was associated with decline only on verbal fluency. The relationships between stroke risk and fluency decline was 80% as large as that between age and fluency decline. Thus, stroke risk could rival the effect of ageing on verbal fluency performance. (RH).
Accession NumberCPA-020107210 A
ClassmarkCQA: CA3: DA: BC: 7T

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