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Centre for Policy on Ageing | |
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| Prevalence and associated behavioral symptoms of depression in mild cognitive impairment and dementia due to Alzheimer's disease | | Author(s) | Stefan Van der Mussele, Kim Bekelaar, Nathalie Le Bastard |
| Journal title | International Journal of Geriatric Psychiatry, vol 28, no 9, September 2013 |
| Publisher | Wiley Blackwell, September 2013 |
| Pages | pp 947-958 |
| Source | www.orangejournal.org |
| Keywords | Depression ; Symptoms ; Dementia ; Cognitive impairment ; Behaviour ; Behaviour disorders ; Evaluation. |
| Annotation | Mild cognitive impairment (MCI) is a clinical concept that categorises subjects who are in an intermediate cognitive state between normal ageing and dementia. The aims of this study were to determine the prevalence of significant depressive symptoms in MCI and Alzheimer's disease (AD) patients and to characterise the behaviour associated with significant depressive symptoms in MCI and AD patients. A cross-sectional analysis of baseline data from a prospective, longitudinal study on behavioural symptoms of dementia and MCI was performed. The study population consisted of 270 MCI and 402 AD patients. Behavioural assessment was performed by means of Middelheim Frontality Score, Behavioural Pathology in Alzheimer's Disease Rating Scale (Behave-AD) and Cohen-Mansfield Agitation Inventory. The presence of significant depressive symptoms was defined as a Cornell Scale for Depression in Dementia total score of 7 or greater. The prevalence of significant depressive symptoms in AD patients (25%) was higher compared with MCI patients (16%). Patients with significant depressive symptoms showed an increased severity of frontal lobe symptoms, behavioural symptoms and agitation. Also most of the individual frontal lobe and behavioural symptoms were more prevalent and severe, resulting in higher Behave-AD global scores. Mild cognitive impairment patients with depressive symptoms showed more severe behavioural symptoms and more severe verbally agitated behaviour than AD patients without depressive symptoms. The study concludes that frontal lobe and behavioural symptoms are more prevalent and severe in MCI and AD patients with significant depressive symptoms as compared with patients without depressive symptoms. (JL). |
| Accession Number | CPA-130830228 A |
| Classmark | ENR: CT: EA: E4: DM: EP: 4C |
Data © Centre for Policy on Ageing |
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| ...from the Ageinfo database published by Centre for Policy on Ageing. |
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