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The presence of leuko-araiosis in patients with Alzheimer's disease predicts poor tolerance to tacrine, but does not discriminate responders from non-responders
Author(s)Khaled Amar, Gordon K Wilcock, Margaret Scott
Journal titleAge and Ageing, vol 26, no 1, January 1997
Pagespp 25-29
KeywordsDementia ; Drugs ; Cognitive processes ; Clinical surveys.
AnnotationApproximately one third of patients with Alzheimer's disease (AD) respond favourably to the anticholinesterase tacrine, but the drug's usefulness is marred by a high incidence of side effects, the commonest being abnormal liver function tests. AD patients with white matter low attenuation (WMLA, or leuko-araiosis) have a significantly higher rate of withdrawal from tacrine.
Accession NumberCPA-970829205 A
ClassmarkEA: LLD: DA: 3G

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