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Association between bone mineral density and cognitive decline in older women
Author(s)Kristine Yaffe, Warren Browner, Jane Cauley,
Journal titleJournal of the American Geriatrics Society, vol 47, no 10, October 1999
Pagespp 1176-1182
KeywordsOsteoporosis ; Dementia ; Older women ; Living in the community ; United States of America.
AnnotationSome recent studies have suggested that oestrogen replacement therapy improves cognition in healthy pre- and post-menopausal women. This study tested the hypothesis that bone mineral density (BMD), a marker of cumulative oestrogen exposure, is associated with cognitive function in non-demented older adults. A total of 8333 older community-dwelling women participated in the study. Compared with women with higher bone mineral density, women with low baseline BMD had up to 8% worse baseline cognitive scores and up to 6% worse repeat cognitive scores, even after multivariate adjustments. Women with vertebral fractures had lower cognitive test scores and a greater odds of cognitive deterioration than those without fractures. The findings indicate that women with osteoporosis have poorer cognitive function and a greater risk of cognitive deterioration. (AKM).
Accession NumberCPA-991201210 A
ClassmarkCLO: EA: BD: K4: 7T

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